The U.S. pharmacy chains CVS, Walmart and Walgreens must pay a combined $650.6 million to two Ohio counties to address the damage done by the opioid epidemic, a federal judge ruled Aug. 17, reports The Guardian.

The order by U.S. judge Dan Polster in Cleveland comes after a jury last November concluded that the firms helped create a public nuisance in Lake and Trumbull counties by oversupplying addictive pain pills, many of which found their way on to the black market. The companies have said they would appeal that verdict.

Polster held a separate non-jury trial earlier this year to decide how much the companies had to pay.

Polster said the sum must be paid over 15 years, with the amount for the first two years, or $86.7 million, to be paid into a fund immediately. The judge also ordered the companies to implement new procedures to combat illegal diversion of opioid drugs.

The U.S. opioid epidemic has caused more than 500,000 overdose deaths over two decades, according to government data. More than 3,300 opioid lawsuits have been filed nationally against drugmakers, distributors and pharmacy chains.

The litigation has resulted in several nationwide settlements, including a $26 billion deal with Johnson & Johnson and the three leading distributors, a $2.37 billion settlement with AbbVie Inc and a $4.25 billion settlement with Teva Pharmaceutical Industries Ltd.

Pharmacies have yet to reach a nationwide settlement.